Back to Search
Start Over
Clinical Significance of Get With the Guidelines-Heart Failure Risk Score in Patients With Chronic Heart Failure After Hospitalization.
- Source :
-
Journal of the American Heart Association [J Am Heart Assoc] 2018 Sep 04; Vol. 7 (17), pp. e008316. - Publication Year :
- 2018
-
Abstract
- Background The Get With the Guidelines-Heart Failure ( GWTG - HF ) risk score was developed using American Heart Association GWTG - HF program data and predicts in-hospital mortality in patients with acute heart failure (HF). We aimed to clarify the prognostic impacts of the GWTG - HF risk score in patients with HF after discharge. Methods and Results We examined the GWTG - HF score in 1452 patients with HF, who were admitted to our hospital and discharged after treatment, by calculating 7 predetermined variables. We divided all subjects into 3 groups according to the GWTG - HF risk score (low, moderate, and high score groups). The plasma B-type natriuretic peptide level significantly increased with increasing GWTG - HF risk score severity (median values of B-type natriuretic peptide: 167.0 in low, 260.7 in moderate, and 418.2 pg/mL in high score groups). We followed up all subjects after discharge, and there were 347 (23.9%) all-cause deaths and 407 (28.0%) cardiac events in follow-up periods. A Kaplan-Meier survival curve demonstrated that event rates of all-cause death and cardiovascular events, including worsening HF and cardiac death, significantly increased with increasing GWTG - HF risk score severity in all subjects, and also in 749 patients with HF with preserved ejection fraction (ejection fraction ≥50%) and 703 patients with HF with reduced ejection fraction (ejection fraction <50%) patients. The multivariable Cox proportional hazard regression analysis demonstrated that the GWTG - HF risk score was one of the significant predictors of all-cause mortality and cardiac events (all-cause mortality: hazard ratio, 1.537, 95% confidence interval, 1.172-2.023; cardiac events: hazard ratio, 1.584, 95% confidence interval, 1.344-1.860, per 10-point increase of GWTG - HF score). Conclusions The GWTG - HF risk score is a useful multivariable score model for several years after hospitalization in patients with HF in a Japanese population.
- Subjects :
- Acute Disease
Adult
Age Factors
Aged
Blood Pressure
Blood Urea Nitrogen
Cause of Death
Chronic Disease
Comorbidity
Disease Progression
Ethnicity
Female
Heart Failure epidemiology
Heart Failure physiopathology
Heart Rate
Hospital Mortality
Humans
Japan epidemiology
Kaplan-Meier Estimate
Male
Middle Aged
Mortality
Multivariate Analysis
Prognosis
Proportional Hazards Models
Prospective Studies
Pulmonary Disease, Chronic Obstructive epidemiology
Risk Assessment
Sodium blood
Heart Diseases mortality
Heart Failure blood
Hospitalization statistics & numerical data
Natriuretic Peptide, Brain blood
Subjects
Details
- Language :
- English
- ISSN :
- 2047-9980
- Volume :
- 7
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Journal of the American Heart Association
- Publication Type :
- Academic Journal
- Accession number :
- 30371158
- Full Text :
- https://doi.org/10.1161/JAHA.117.008316