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Genome-wide epigenetic landscape of pig lincRNAs and their evolution during porcine domestication.
- Source :
-
Epigenomics [Epigenomics] 2018 Dec; Vol. 10 (12), pp. 1603-1618. Date of Electronic Publication: 2018 Oct 29. - Publication Year :
- 2018
-
Abstract
- Aim: We aimed to identify previously unreported long intergenic noncoding RNAs (lincRNAs) in the porcine liver, an important metabolic tissue, and further illustrate the epigenomic landscapes and the evolution of lincRNAs.<br />Materials & Methods: We used porcine omics data and comprehensively analyzed and identified lincRNAs and their methylation, expression and evolutionary patterns during pig domestication.<br />Results: LincRNAs exhibit highly methylated promoter and downstream regions, as well as lower expression levels and higher tissue specificity than protein-coding genes. We identified a batch of lincRNAs with selection signals that are associated with pig domestication, which are more highly expressed in the liver than in other tissues (19:10/8/6/3/2/1/1). Interestingly, the lincRNA linc-sscg1779 and its target gene C6, which is crucial in liver metabolism, are differentially expressed during pig domestication.<br />Conclusion: Although they may originate from noisy transcripts, lincRNAs may be subjected to artificial selection. This phenomenon implies the functional importance of lincRNAs in pig domestication.
- Subjects :
- Animals
Biological Evolution
DNA, Intergenic genetics
Domestication
Gene Expression Profiling veterinary
Liver physiology
Organ Specificity
Promoter Regions, Genetic genetics
Sequence Analysis, RNA veterinary
DNA Methylation
Epigenomics
Genome genetics
RNA, Long Noncoding genetics
Swine genetics
Transcriptome
Subjects
Details
- Language :
- English
- ISSN :
- 1750-192X
- Volume :
- 10
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Epigenomics
- Publication Type :
- Academic Journal
- Accession number :
- 30371096
- Full Text :
- https://doi.org/10.2217/epi-2017-0117