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Medical therapy for non-functioning pituitary tumors-a critical approach.
- Source :
-
Hormones (Athens, Greece) [Hormones (Athens)] 2019 Jun; Vol. 18 (2), pp. 117-126. Date of Electronic Publication: 2018 Oct 27. - Publication Year :
- 2019
-
Abstract
- Non-functioning pituitary adenomas (NFPAs) are the second most common variant of pituitary tumors. When symptomatic, primary therapy is surgery. Recurrence rates are high. Since many NFPAs express dopamine and somatostatin receptors, medical therapy has been used after surgery in order to prevent recurrence. So far, dopamine agonists have been more widely tested with some promise when introduced immediately after surgery but with less efficacy when introduced later upon tumor regrowth. Currently, the role of medical therapy to prevent tumor regrowth in NFPAs is limited by imprecisions as to final outcome and uncertainties concerning on patient selection, dosing, duration, and side effects.
- Subjects :
- Adenoma complications
Adenoma pathology
Adenoma surgery
Chemotherapy, Adjuvant methods
Combined Modality Therapy
Dopamine Agonists therapeutic use
Humans
Hypopituitarism drug therapy
Hypopituitarism etiology
Neoplasm Recurrence, Local drug therapy
Neoplasm Recurrence, Local pathology
Pituitary Neoplasms complications
Pituitary Neoplasms pathology
Pituitary Neoplasms surgery
Receptors, Somatostatin antagonists & inhibitors
Adenoma drug therapy
Antineoplastic Agents therapeutic use
Pituitary Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2520-8721
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Hormones (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 30368687
- Full Text :
- https://doi.org/10.1007/s42000-018-0070-0