Back to Search
Start Over
Biocompatibility of common implantable sensor materials in a tumor xenograft model.
- Source :
-
Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2019 Jul; Vol. 107 (5), pp. 1620-1633. Date of Electronic Publication: 2018 Oct 27. - Publication Year :
- 2019
-
Abstract
- Real-time monitoring of tumor microenvironment parameters using an implanted biosensor could provide valuable information on the dynamic nature of a tumor's biology and its response to treatment. However, following implantation biosensors may lose functionality due to biofouling caused by the foreign body response (FBR). This study developed a novel tumor xenograft model to evaluate the potential of six biomaterials (silicon dioxide, silicon nitride, Parylene-C, Nafion, biocompatible EPOTEK epoxy resin, and platinum) to trigger a FBR when implanted into a solid tumor. Biomaterials were chosen based on their use in the construction of a novel biosensor, designed to measure spatial and temporal changes in intra-tumoral O <subscript>2</subscript> , and pH. None of the biomaterials had any detrimental effect on tumor growth or body weight of the murine host. Immunohistochemistry showed no significant changes in tumor necrosis, hypoxic cell number, proliferation, apoptosis, immune cell infiltration, or collagen deposition. The absence of biofouling supports the use of these materials in biosensors; future investigations in preclinical cancer models are required, with a view to eventual applications in humans. To our knowledge this is the first documented investigation of the effects of modern biomaterials, used in the production of implantable sensors, on tumor tissue after implantation. © 2018 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals, Inc. J Biomed Mater Res Part B, 2018. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1620-1633, 2019.<br /> (© 2018 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals, Inc.)
- Subjects :
- Animals
Biocompatible Materials metabolism
Biosensing Techniques methods
Cell Line, Tumor
Collagen chemistry
Epoxy Resins chemistry
Female
Fluorocarbon Polymers chemistry
Humans
Mice
Neoplasms, Experimental
Platinum chemistry
Polymers chemistry
Silicon Compounds chemistry
Silicon Dioxide chemistry
Smart Materials metabolism
Tumor Microenvironment drug effects
Xylenes chemistry
Biocompatible Materials chemistry
Foreign-Body Reaction pathology
Prostheses and Implants
Smart Materials chemistry
Transplantation, Heterologous methods
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4981
- Volume :
- 107
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of biomedical materials research. Part B, Applied biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 30367816
- Full Text :
- https://doi.org/10.1002/jbm.b.34254