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Role of Taste Receptors as Sentinels of Innate Immunity in the Upper Airway.
- Source :
-
Journal of pathogens [J Pathog] 2018 Oct 01; Vol. 2018, pp. 9541987. Date of Electronic Publication: 2018 Oct 01 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Evidence is emerging that shows taste receptors serve functions outside of taste sensation of the tongue. Taste receptors have been found in tissue across the human body, including the gastrointestinal tract, bladder, brain, and airway. These extraoral taste receptors appear to be important in modulating the innate immune response through detection of pathogens. This review discusses taste receptor signaling, focusing on the G-protein-coupled receptors that detect bitter and sweet compounds in the upper airway epithelium. Emphasis is given to recent studies which link the physiology of sinonasal taste receptors to clinical manifestation of upper airway disease.
Details
- Language :
- English
- ISSN :
- 2090-3057
- Volume :
- 2018
- Database :
- MEDLINE
- Journal :
- Journal of pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 30363975
- Full Text :
- https://doi.org/10.1155/2018/9541987