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In vitro evaluation of a new nitrosourea, TCNU, against human small cell lung cancer cell lines.
- Source :
-
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 1987; Vol. 19 (4), pp. 315-8. - Publication Year :
- 1987
-
Abstract
- The cytotoxic activity of a new nitrosourea, TCNU, was compared with that of BCNU in five human small cell lung cancer cell lines in vitro. TCNU was found to be equivalent or inferior to BCNU when compared on a microgram to microgram basis. If the potential of in vitro phase II trials for selection of new drugs can be validated, it can be concluded that TCNU is not superior to other nitrosoureas for the treatment of SCCL.
- Subjects :
- Carmustine therapeutic use
Cell Cycle drug effects
Cell Line
Drug Evaluation, Preclinical
Flow Cytometry
Humans
Taurine therapeutic use
Carcinoma, Small Cell drug therapy
Colony-Forming Units Assay
Lung Neoplasms drug therapy
Nitrosourea Compounds therapeutic use
Taurine analogs & derivatives
Tumor Stem Cell Assay
Subjects
Details
- Language :
- English
- ISSN :
- 0344-5704
- Volume :
- 19
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer chemotherapy and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 3036388
- Full Text :
- https://doi.org/10.1007/BF00261480