Back to Search
Start Over
Cytogenetic and molecular genetic studies of a patient with atypical lymphoid hyperplasia.
- Source :
-
Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 1987 Aug; Vol. 27 (2), pp. 251-9. - Publication Year :
- 1987
-
Abstract
- We have karyotyped cells from a lymph node of a patient with atypical lymphoid hyperplasia. Among other clonal chromosomal abnormalities, a t(2;19) translocation was observed with breakpoints at 2p11.2 and 19q13. The genes for transforming growth factor alpha and beta have been mapped to 2p11-p13 and 19q13, respectively, but Southern blot analysis did not reveal any alteration in the structure of these genes. Similarly, the kappa immunoglobulin gene, which maps to 2p11-p12 was not rearranged. In addition, Southern blot analysis using immunoglobulin and T-cell receptor genes as probes, did not demonstrate any clonality of either B or T cells. We propose that this patient represents an early, polyclonal stage of atypical hyperplasia. The chromosome changes observed may have been one of the etiologic factors causing this disorder.
Details
- Language :
- English
- ISSN :
- 0165-4608
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer genetics and cytogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 3036340
- Full Text :
- https://doi.org/10.1016/0165-4608(87)90007-0