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Ultrasmall hybrid protein-copper sulfide nanoparticles for targeted photoacoustic imaging of orthotopic hepatocellular carcinoma with a high signal-to-noise ratio.
- Source :
-
Biomaterials science [Biomater Sci] 2018 Dec 18; Vol. 7 (1), pp. 92-103. - Publication Year :
- 2018
-
Abstract
- Although photoacoustic imaging combined with second near infrared (NIR II) molecular probes for tumor diagnosis has drawn tremendous attention during the past few decades, the targeted photoacoustic imaging of orthotopic hepatocellular carcinoma (HCC) still remains a challenge due to high liver vascularization and non-specificity of probes in liver tumors. Herein, we report on cyclic arginine-glycine-aspartic acid (cRGD) peptide conjugated ultrasmall CuS nanoparticles (CuS@BSA-RGD NPs) which encapsulate bovine serum albumin (BSA) and possess high optical absorption at 1064 nm. The encapsulation of BSA results in great biocompatibility of CuS@BSA-RGD NPs along with excellent photostability and physiological stability. The cRGD conjugation enables the improvement of tumor uptake of CuS@BSA-RGD NPs by virtue of its positive tumor cell targeting capability. The efficient accumulation of CuS@BSA-RGD NPs in the tumor over time after intravenous administration to orthotopic HCC bearing mice was achieved, which resulted in highly sensitive photoacoustic visualization of the tumor region. Toxicity studies indicate that CuS@BSA-RGD NPs exhibited negligible systemic toxicity in vivo. The results demonstrate that the CuS@BSA-RGD NPs might hold great promise for future imaging and diagnosis of cancer.
- Subjects :
- Animals
Copper administration & dosage
Copper pharmacokinetics
Diagnostic Imaging methods
Male
Mice, Inbred BALB C
Mice, Nude
Nanoparticles administration & dosage
Peptides, Cyclic administration & dosage
Peptides, Cyclic pharmacokinetics
Serum Albumin, Bovine administration & dosage
Serum Albumin, Bovine pharmacokinetics
Signal-To-Noise Ratio
Sulfides administration & dosage
Sulfides pharmacokinetics
Whole Body Imaging methods
Carcinoma, Hepatocellular diagnostic imaging
Copper chemistry
Liver Neoplasms diagnostic imaging
Nanoparticles chemistry
Peptides, Cyclic chemistry
Photoacoustic Techniques methods
Serum Albumin, Bovine chemistry
Sulfides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2047-4849
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biomaterials science
- Publication Type :
- Academic Journal
- Accession number :
- 30358774
- Full Text :
- https://doi.org/10.1039/c8bm00767e