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Rotavirus Vaccine Take in Infants Is Associated With Secretor Status.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2019 Feb 15; Vol. 219 (5), pp. 746-749. - Publication Year :
- 2019
-
Abstract
- Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take") among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2-8.1; P = .016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of "take" for any particular rotavirus vaccine may differ across populations based on HBGAs.<br /> (Published by Oxford University Press for the Infectious Diseases Society of America 2018.)
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 219
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 30357332
- Full Text :
- https://doi.org/10.1093/infdis/jiy573