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Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe.
- Source :
-
The Analyst [Analyst] 2018 Nov 19; Vol. 143 (23), pp. 5799-5804. - Publication Year :
- 2018
-
Abstract
- A two-photon fluorescent probe, TP-2Bz, was designed and synthesized and it exhibited good targeting capabilities toward cell nuclei. In particular, TP-2Bz demonstrated a high selectivity to both G-quadruplex DNA and viscosity inside the nucleus with significant ratiometric enhancement in fluorescence, providing a specific, versatile imaging tool for analyzing the viscosity and G-quadruplex DNA in living cells.
Details
- Language :
- English
- ISSN :
- 1364-5528
- Volume :
- 143
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- The Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 30357116
- Full Text :
- https://doi.org/10.1039/c8an01643g