Back to Search
Start Over
Neuroprotective, antidiabetic and antioxidant effect of Hedera nepalensis and lupeol against STZ + AlCl 3 induced rats model.
- Source :
-
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences [Daru] 2018 Dec; Vol. 26 (2), pp. 179-190. Date of Electronic Publication: 2018 Oct 23. - Publication Year :
- 2018
-
Abstract
- Purpose: This study was aimed to evaluate the effect of Hedera nepalensis crude extract (HNC) and its isolated compound lupeol on antioxidant defence system, biochemical parameters and behavioural indices of Alzheimer disease generated in diabetic rats.<br />Methods: To evaluate the effect of the plant extract and lupeol, symptoms of Alzheimer and diabetes were induced in rats by STZ + AlCl <subscript>3</subscript> treatment. Glucose level was measured with glucometer followed by antioxidant and biochemical assessment of the treated and untreated animals. Behavioural response of the rats was determined by Elevated Plus Maze (EPM) test and Morris Water Maze (MWM) test followed by determination of brain neurotransmitters by HPLC.<br />Results: HNC significantly reduced blood glucose level in a time dependent manner and elevated liver function markers were significantly (P < 0.05) reinstated to normal levels. HNC showed increase in level of catalase (CAT), superoxide dismutase (SOD) and reduced glutathione (GSH). HPLC quantification revealed that HNC treatment led to significant (p < 0.001) elevation in the level of neurotransmitters (dopamine and serotonin) in the midbrain region as compared to Alzheimer control (AC) group. EPM and MWM test showed decrease in cognitive and memory impairment in a rat group treated with HNC as compared to AC group.<br />Conclusion: Overall, results showed that H. nepalensis has therapeutic potential for the treatment of diseases like Alzheimer and diabetes. Graphical abstract Therapeutic effect of Hedera nepalensis K. Koch and lupeol against STZ + AICI <subscript>3</subscript> induced diabetic rats model.
- Subjects :
- Aluminum Chloride adverse effects
Alzheimer Disease chemically induced
Alzheimer Disease metabolism
Animals
Antioxidants chemistry
Antioxidants pharmacology
Catalase metabolism
Diabetes Mellitus, Experimental metabolism
Dopamine metabolism
Glutathione metabolism
Hypoglycemic Agents chemistry
Hypoglycemic Agents pharmacology
Male
Mesencephalon metabolism
Pentacyclic Triterpenes pharmacology
Plant Extracts pharmacology
Rats
Serotonin metabolism
Streptozocin
Superoxide Dismutase metabolism
Time Factors
Alzheimer Disease drug therapy
Antioxidants administration & dosage
Diabetes Mellitus, Experimental drug therapy
Hedera chemistry
Hypoglycemic Agents administration & dosage
Pentacyclic Triterpenes administration & dosage
Plant Extracts administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2008-2231
- Volume :
- 26
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30353379
- Full Text :
- https://doi.org/10.1007/s40199-018-0223-3