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Chemodivergent and Stereoselective Access to Fused Isoxazoline Azetidines and Thietanes through [3 + 2]-Cycloadditions.
- Source :
-
Organic letters [Org Lett] 2018 Nov 02; Vol. 20 (21), pp. 6736-6740. Date of Electronic Publication: 2018 Oct 23. - Publication Year :
- 2018
-
Abstract
- By combining efficient methodologies for the preparation of substituted azetines and thietes with a highly regio- and diastereoselective [3 + 2]-cycloaddition, a straightforward pathway for the synthesis of fused isoxazoline azetidines and thietanes has been designed. With minimal steps and starting from commercial sources, a new library of elaborated architectures was synthesized opening up a new class of molecules with large potential in pharmacology. Finally, a retro [2 + 2]-cycloaddition leading to substituted isoxazoles is described.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 20
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 30351958
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b02848