Forecasting role of genetic markers in outlining features of pneumoconiosis course in post-contact period.

Based on studies of certain gene-candidate polymorphism, the authors studied markers of early development and unfavorable course of pneumoconiosis in post-contact period. Analysis covered occurrence of genotypes and allels of I/D polymorphism of gene CCRS, 4a/b polymorphism of gene NOS3, VNTR polymorphism of gene ILRN, I/D polymorphism of CASP8 and mutation GLU342LYS (rs28929474) and GLU264VAL (rsl7S80) in gene SERPINAl in patients with various terms of pneumoconiosis formation. Findings are individual criteria of early formation and progress of pneumoconiosis in post-contact period..