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Saturated phospholipids are required for nano- to micron-size transformation of cholesterol-containing liposomes upon QS21 addition.
- Source :
-
Journal of liposome research [J Liposome Res] 2019 Sep; Vol. 29 (3), pp. 247-250. Date of Electronic Publication: 2018 Nov 23. - Publication Year :
- 2019
-
Abstract
- Liposomes containing cholesterol and monophosphoryl lipid A (such as ALFQ and AS01B) are vaccine adjuvants. During construction of the formulations, addition of QS21 to nano-size (50-100 nm) liposomes resulted in extremely large (up to ∼30 µm) liposomes in ALFQ, but AS01B liposomes remained small nano-vesicles. Here, we show that saturation of phospholipid chains is essential for production of large liposomes by QS21.
Details
- Language :
- English
- ISSN :
- 1532-2394
- Volume :
- 29
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of liposome research
- Publication Type :
- Academic Journal
- Accession number :
- 30350748
- Full Text :
- https://doi.org/10.1080/08982104.2018.1538239