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Effect of Salmonella typhimurium porins on the cardiovascular and renal apparatus.
- Source :
-
Journal of medicine [J Med] 1986; Vol. 17 (5-6), pp. 285-97. - Publication Year :
- 1986
-
Abstract
- The cardiovascular effects of porins were evaluated using porins isolated from Salmonella typhimurium SH5014. In dogs porins depress arterial systemic pressure, vasomotor reactivity of norepinephrine and peripheral vagal stimulation. They are capable of modifying the sinocarotidal baroreceptor reactivity. In mice porins increase the cardiotoxic effects of isoprenaline, thyroxine, emetine and of p-nitrophenol. In rats porins increase the arrhythmogenic and lethal effects of BaCl2 and also give rise to renal lesions, probably at the tubular level.
- Subjects :
- Animals
Barium pharmacology
Cardiomyopathies chemically induced
Dogs
Drug Synergism
Electrocardiography
Emetine pharmacology
Isoproterenol pharmacology
Male
Mice
Nitrophenols pharmacology
Porins
Rats
Respiration drug effects
Thyroxine pharmacology
Bacterial Outer Membrane Proteins pharmacology
Barium Compounds
Blood Pressure drug effects
Chlorides
Heart Rate drug effects
Kidney drug effects
Salmonella typhimurium
Subjects
Details
- Language :
- English
- ISSN :
- 0025-7850
- Volume :
- 17
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 3035043