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Shensong Yangxin capsule reduces atrial fibrillation susceptibility by inhibiting atrial fibrosis in rats with post-myocardial infarction heart failure.
- Source :
-
Drug design, development and therapy [Drug Des Devel Ther] 2018 Oct 10; Vol. 12, pp. 3407-3418. Date of Electronic Publication: 2018 Oct 10 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Purpose: Shensong Yangxin (SSYX) capsule is a traditional Chinese medicine that has been used widely to treat cardiac arrhythmia. This study aimed to assess whether SSYX prevents atrial fibrillation (AF) after chronic myocardial infarction (MI)-induced heart failure and to determine the underlying mechanisms.<br />Materials and Methods: The study included 45 male Sprague Dawley rats. The rats underwent MI induction or sham surgery. One week after MI induction surgery, we performed serial echocardiography and administered SSYX capsule to some rats that experienced MI. After 4 weeks of treatment, AF inducibility was assessed with transesophageal programmed electrical stimulation technology. Additionally, multielectrode array assessment, histological analysis, and Western blot analysis were performed.<br />Results: AF inducibility was significantly lower in SSYX rats than in MI rats (33.3% vs 73.3%, P <0.05). Additionally, conduction velocities in the left atrium were greater in SSYX rats than in MI rats. Moreover, SSYX decreased left atrial fibrosis, downregulated TGF-β1, MMP-9, TIMP-I, and type I and III collagen expressions, and inhibited the differentiation of cardiac fibroblasts to myofibroblasts.<br />Conclusion: SSYX reduces AF inducibility after MI by improving left atrial conduction function via the inhibition of left atrial fibrosis. It prevents the development of an MI-induced vulnerable substrate for AF.<br />Competing Interests: Disclosure The authors report no conflicts of interest in this work.
- Subjects :
- Animals
Atrial Fibrillation metabolism
Capsules administration & dosage
Capsules chemistry
Capsules pharmacology
Drugs, Chinese Herbal administration & dosage
Drugs, Chinese Herbal chemistry
Echocardiography
Heart Failure metabolism
Male
Medicine, Chinese Traditional
Microelectrodes
Myocardial Infarction metabolism
Rats
Rats, Sprague-Dawley
Atrial Fibrillation drug therapy
Drugs, Chinese Herbal pharmacology
Heart Failure drug therapy
Myocardial Infarction drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1177-8881
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Drug design, development and therapy
- Publication Type :
- Academic Journal
- Accession number :
- 30349194
- Full Text :
- https://doi.org/10.2147/DDDT.S182834