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γ-Tubulin⁻γ-Tubulin Interactions as the Basis for the Formation of a Meshwork.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2018 Oct 19; Vol. 19 (10). Date of Electronic Publication: 2018 Oct 19. - Publication Year :
- 2018
-
Abstract
- In cytoplasm, protein γ-tubulin joins with various γ-tubulin complex proteins (GCPs) to form a heterotetramer γ-tubulin small complex (γ-TuSC) that can grow into a ring-shaped structure called the γ-tubulin ring complex (γ-TuRC). Both γ-TuSC and γ-TuRC are required for microtubule nucleation. Recent knowledge on γ-tubulin with regard to its cellular functions beyond participation in its creation of microtubules suggests that this protein forms a cellular meshwork. The present review summarizes the recognized functions of γ-tubulin and aims to unite the current views on this protein.
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 19
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30347727
- Full Text :
- https://doi.org/10.3390/ijms19103245