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Drug-induced aortitis in a patient with ovarian cancer treated with bevacizumab combination therapy.
- Source :
-
Taiwanese journal of obstetrics & gynecology [Taiwan J Obstet Gynecol] 2018 Oct; Vol. 57 (5), pp. 750-752. - Publication Year :
- 2018
-
Abstract
- Objective: To review and evaluate drug-induced vasculitis, which is an extremely rare complication of chemotherapy.<br />Case Report: A 47-year-old woman with ovarian cancer developed aortitis during bevacizumab combination chemotherapy. Contract-enhanced CT showed concentric thickening of the descending aorta. Antibiotics were administered, but a repeat CE-CT scan showed no resolution of the aortitis. To treat the aortitis, she was started on oral prednisolone. A subsequent CE-CT scan showed no signs of aortitis. She was thus re-started on a modified chemotherapy regimen.<br />Conclusion: Aortitis should be considered in patients receiving bevacizumab combination therapy who develop persistent fever and upper-abdominal pain. Contrast-enhanced CT is useful for detecting drug-induced aortitis.<br /> (Copyright © 2018. Published by Elsevier B.V.)
- Subjects :
- Anti-Bacterial Agents therapeutic use
Antineoplastic Combined Chemotherapy Protocols
Aortitis diagnostic imaging
Aortitis drug therapy
Contrast Media
Female
Humans
Middle Aged
Prednisolone therapeutic use
Tomography, X-Ray Computed methods
Aortitis chemically induced
Bevacizumab adverse effects
Ovarian Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1875-6263
- Volume :
- 57
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Taiwanese journal of obstetrics & gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 30342665
- Full Text :
- https://doi.org/10.1016/j.tjog.2018.08.026