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Reduced hsa-miR-124-3p levels are associated with the poor survival of patients with hepatocellular carcinoma.

Reduced hsa-miR-124-3p levels are associated with the poor survival of patients with hepatocellular carcinoma.

Authors :
Long HD
Ma YS
Yang HQ
Xue SB
Liu JB
Yu F
Lv ZW
Li JY
Xie RT
Chang ZY
Lu GX
Xie WT
Fu D
Pang LJ
Source :
Molecular biology reports [Mol Biol Rep] 2018 Dec; Vol. 45 (6), pp. 2615-2623. Date of Electronic Publication: 2018 Oct 19.
Publication Year :
2018

Abstract

Hsa-MicroRNA-124a-3p (hsa-miR-124-3p) is involved in tumor progression in certain malignant tumors. However, its function and clinical implication in hepatocellular carcinoma (HCC) have not yet been illustrated. In this study, we explored the expression and prognostic value of hsa-miR-124-3p in patients with HCC. Hsa-miR-124-3p expression in HCC was analyzed in silico, which was subsequently confirmed by quantitative PCR in 155 HCC biopsy samples. Overall survival (OS) and disease-free survival in HCC patients was evaluated by Kaplan-Meier survival analysis, and univariate and multivariate Cox proportional hazard models were used. The in silico results demonstrated that hsa-miR-124-3p was reduced in cell lines and tissues of HCC, and hsa-miR-124-3p expression was lower in HCC tumor samples than in normal liver tissues. Moreover, a decrease in hsa-miR-124-3p expression was closely correlated with tumor diameter (≥ 5 cm) and number of lesions (multiple). Lower hsa-miR-124-3p expression was shown to be correlated with a shorter OS and poor prognosis in HCC. Our findings demonstrate that hsa-miR-124-3p might be a potential target for the diagnosis and prognosis of HCC.

Details

Language :
English
ISSN :
1573-4978
Volume :
45
Issue :
6
Database :
MEDLINE
Journal :
Molecular biology reports
Publication Type :
Academic Journal
Accession number :
30341691
Full Text :
https://doi.org/10.1007/s11033-018-4431-1