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Association between CTSS gene polymorphism and the risk of acute atherosclerotic cerebral infarction in Chinese population: a case-control study.
- Source :
-
Bioscience reports [Biosci Rep] 2018 Nov 20; Vol. 38 (6). Date of Electronic Publication: 2018 Nov 20 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Objective: To investigate the association between the gene polymorphisms of rs774320676, rs768437857, rs928508030, and rs2275235 loci of Cathepsin S (CTSS) and risk of acute atherosclerotic cerebral infarction. Methods: A total of 315 patients with acute atherosclerotic cerebral infarction (study group) and 220 healthy subjects (control group) were enrolled in the present study. The genetic polymorphism of rs774320676, rs768437857, rs928508030, and rs2275235 loci of CTSS of subjects was analyzed by PCR-Sanger sequencing. Results: The proportion of carriers with mutant T allele at rs774320676 locus and mutant G allele at rs928508030 locus of CTSS in study group was significantly higher than the proportion in control group ( P =0.000, adjusted odds ratio (OR) = 1.332, 95% confidence interval (CI) = 1.200-1.460; P <0.001, adjusted OR = 1.185, 95% CI = 1.055-1.314; P =0.002). The T allele at rs774320676 locus and the G allele at rs928508030 locus of CTSS were independent risk factors for acute atherosclerotic cerebral infarction (OR = 2.534, 95% CI = 1.020-4.652, P =0.006; OR = 2.016, 95% CI = 1.031-4.385, P =0.031). Conclusion: The single nucleotide polymorphisms (SNPs) of rs774320676 and rs928508030 of CTSS gene were related with risk for acute atherosclerotic cerebral infarction. The T allele at rs774320676 locus and G allele at rs928508030 locus of CTSS were genetic susceptibility genes of acute atherosclerotic cerebral infarction.<br /> (© 2018 The Author(s).)
- Subjects :
- Aged
Alleles
Cerebral Infarction physiopathology
China epidemiology
Female
Gene Frequency
Genetic Association Studies
Genotype
Humans
Intracranial Arteriosclerosis physiopathology
Male
Middle Aged
Polymorphism, Single Nucleotide genetics
Risk Factors
Cathepsins genetics
Cerebral Infarction genetics
Genetic Predisposition to Disease
Intracranial Arteriosclerosis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4935
- Volume :
- 38
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioscience reports
- Publication Type :
- Academic Journal
- Accession number :
- 30341237
- Full Text :
- https://doi.org/10.1042/BSR20180586