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Combined treatment of severe essential hypertension with the new angiotensin converting enzyme inhibitor ramipril.
- Source :
-
The American journal of cardiology [Am J Cardiol] 1987 Apr 24; Vol. 59 (10), pp. 143D-148D. - Publication Year :
- 1987
-
Abstract
- Ramipril is a newly synthesized angiotensin converting enzyme inhibitor without a sulfhydryl group in the molecule but with a prolonged duration of action. Efficacy, tolerance and safety of this drug were evaluated in 10 patients with severe essential hypertension. After a treatment period of at least 4 weeks with the conventional antihypertensive drug combination of a diuretic and a beta-blocking agent with the vasodilator dihydralazine, their systolic and diastolic blood pressures averaged 161 +/- 6 and 111 +/- 2 mm Hg, respectively. Because diastolic blood pressure during this drug regimen was still greater than 105 mm Hg in all patients, the patients received ramipril initially at single daily doses of 5 mg in addition to their previous medication. The first dose of 5 mg ramipril resulted in a moderate but significant decrease in systolic and diastolic blood pressure in 9 of the 10 patients to 142 +/- 5 and 104 +/- 4 mm Hg (p less than 0.01), respectively, between 3 and 6 hours after drug administration. In 1 patient blood pressure was unresponsive to ramipril and 1 patient complained of nausea and vomiting within the first week of treatment with ramipril. Within the following 8-week treatment period with a once-daily intake of 5 or, if necessary, 10 mg of ramipril, diastolic blood pressure normalized in the remaining 8 patients to less than 90 mm Hg. Systolic and diastolic blood pressure averaged 130 +/- 5 and 83 +/- 2 mm Hg, respectively, at the end of the 8-week treatment period with ramipril. Severe hypotension and reflex tachycardia were not observed.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Adult
Antihypertensive Agents adverse effects
Bridged Bicyclo Compounds adverse effects
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Ramipril
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents therapeutic use
Blood Pressure drug effects
Bridged Bicyclo Compounds therapeutic use
Bridged-Ring Compounds therapeutic use
Heart Rate drug effects
Hypertension drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 59
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 3034023
- Full Text :
- https://doi.org/10.1016/0002-9149(87)90069-5