Back to Search
Start Over
Corticosterone and pyridostigmine/DEET exposure attenuate peripheral cytokine expression: Supporting a dominant role for neuroinflammation in a mouse model of Gulf War Illness.
- Source :
-
Neurotoxicology [Neurotoxicology] 2019 Jan; Vol. 70, pp. 26-32. Date of Electronic Publication: 2018 Oct 16. - Publication Year :
- 2019
-
Abstract
- Gulf War Illness (GWI) is a chronic multi-symptom disorder experienced by as many as a third of the veterans of the 1991 Gulf War; the constellation of "sickness behavior" symptoms observed in ill veterans is suggestive of a neuroimmune involvement. Various chemical exposures and conditions in theater have been implicated in the etiology of the illness. Previously, we found that GW-related organophosphates (OPs), such as the sarin surrogate, DFP, and chlorpyrifos, cause neuroinflammation. The combination of these exposures with exogenous corticosterone (CORT), mimicking high physiological stress, exacerbates the observed neuroinflammation. The potential relationship between the effects of OPs and CORT on the brain versus inflammation in the periphery has not been explored. Here, using our established GWI mouse model, we investigated the effects of CORT and DFP exposure, with or without a chronic application of pyridostigmine bromide (PB) and N,N-diethyl-meta-toluamide (DEET), on cytokines in the liver and serum. While CORT primed DFP-induced neuroinflammation, this effect was largely absent in the periphery. Moreover, the changes found in the peripheral tissues do not correlate with the previously reported neuroinflammation. These results not only support GWI as a neuroimmune disorder, but also highlight the separation between central and peripheral effects of these exposures.<br /> (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Cholinesterase Inhibitors administration & dosage
Cholinesterase Inhibitors toxicity
Corticosterone administration & dosage
Cytokines antagonists & inhibitors
Cytokines genetics
DEET administration & dosage
Disease Models, Animal
Gene Expression
Inflammation blood
Inflammation chemically induced
Inflammation Mediators antagonists & inhibitors
Insect Repellents administration & dosage
Insect Repellents toxicity
Male
Mice
Mice, Inbred C57BL
Persian Gulf Syndrome chemically induced
Pyridostigmine Bromide administration & dosage
Corticosterone toxicity
Cytokines biosynthesis
DEET toxicity
Inflammation Mediators blood
Persian Gulf Syndrome blood
Pyridostigmine Bromide toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9711
- Volume :
- 70
- Database :
- MEDLINE
- Journal :
- Neurotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 30339781
- Full Text :
- https://doi.org/10.1016/j.neuro.2018.10.006