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Effects of myo-inositol on glucose variability in women with gestational diabetes.
- Source :
-
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2018 Oct; Vol. 22 (19), pp. 6567-6572. - Publication Year :
- 2018
-
Abstract
- Objective: Myo-inositol supplementation prevents gestational diabetes (GDM) in women at risk and reduces insulin resistance in women with GDM. No data are available about its effect on glucose variability. The aim of this study was to evaluate the effects of a supplementation of myo-inositol on glucose variability in women with GDM.<br />Patients and Methods: Myo-inositol effect on glucose variability was studied in a pilot case-control study involving 12 consecutive pregnant women (median age 34 years, 25.0% insulin-treated) with GDM. Six women received myo-inositol 2 g plus 200 mg folic acid twice a day, the others received only folic acid. Information on side effects was collected. A continuous glucose monitoring system was wore before and at the beginning of the supplementation. Mean amplitude of glucose excursion (MAGE), standard deviation (SD) and variability coefficient were the indexes of glucose variability.<br />Results: Myo-inositol lowered glucose levels in the first days after the treatment was started. However, pre-post supplementation overall mean glucose difference was similar between groups (-4.8 vs. 5.0 mg/dL for controls and treated, respectively; p = 0.79). Pre-post differences in SD (13.7 vs. 6.0; p < 0.001), MAGE (3.5 vs.-1.5; p < 0.001) and variability coefficient (0.14 vs. 0.02; p < 0.001) were improved in myo-inositol group. No side effects were recorded.<br />Conclusions: Myo-inositol is effective in reducing glucose variability in women with GDM. It could be a useful strategy for treating GDM.
- Subjects :
- Adult
Biomarkers blood
Blood Glucose metabolism
Case-Control Studies
Diabetes, Gestational blood
Diabetes, Gestational diagnosis
Down-Regulation
Female
Humans
Hypoglycemic Agents adverse effects
Inositol adverse effects
Pilot Projects
Pregnancy
Treatment Outcome
Blood Glucose drug effects
Diabetes, Gestational drug therapy
Dietary Supplements adverse effects
Hypoglycemic Agents therapeutic use
Inositol therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2284-0729
- Volume :
- 22
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- European review for medical and pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30338829
- Full Text :
- https://doi.org/10.26355/eurrev_201810_16073