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Swine antibody-dependent cellular cytotoxicity against pseudorabies virus-infected cells.
- Source :
-
American journal of veterinary research [Am J Vet Res] 1987 Mar; Vol. 48 (3), pp. 481-5. - Publication Year :
- 1987
-
Abstract
- In pseudorabies virus (PRV) infection of pigs, antibody-dependent cellular cytotoxicity (ADCC) may be an early defense mechanism. Peripheral blood leukocytes (PBL) and pulmonary macrophages mediate ADCC activity. Antibody-dependent cellular cytotoxicity against PRV-infected target cells was assessed, and the effect of infection of cells having an ADCC-effector function was determined. Although pulmonary lavage cells (PLC) had ADCC activity, in vitro infection of PLC led to PRV replication, loss of cell viability, and loss of ADCC activity. In contrast, infection of PBL did not lead to replication, decreased cell viability, or reduced ADCC activity, compared with those in non-infected controls. Measuring ADCC activity in a longitudinal study revealed that PBL from neonates had lower ADCC activity than did PBL from pigs greater than 3.5 months old. Peripheral blood leukocytes and not PLC may have a greater role in control of PRV dissemination in the pig. The difference in activity between cells from neonates and older pigs might explain, in part, the age dependency in the severity of the disease.
- Subjects :
- Aging
Animals
Cells, Cultured
Female
Herpesvirus 1, Suid physiology
Leukocytes microbiology
Longitudinal Studies
Lung cytology
Macrophages microbiology
Male
Random Allocation
Virus Replication
Antibody-Dependent Cell Cytotoxicity
Herpesvirus 1, Suid immunology
Leukocytes immunology
Macrophages immunology
Swine immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9645
- Volume :
- 48
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of veterinary research
- Publication Type :
- Academic Journal
- Accession number :
- 3032027