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Flavivirus Receptors: Diversity, Identity, and Cell Entry.
- Source :
-
Frontiers in immunology [Front Immunol] 2018 Sep 26; Vol. 9, pp. 2180. Date of Electronic Publication: 2018 Sep 26 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for significant mortality and morbidity worldwide. The genus comprises more than seventy small, positive-sense, single-stranded RNA viruses, which are responsible for a spectrum of human and animal diseases ranging in symptoms from mild, influenza-like infection to fatal encephalitis and haemorrhagic fever. Despite genomic and structural similarities across the genus, infections by different flaviviruses result in disparate clinical presentations. This review focusses on two haemorrhagic flaviviruses, dengue virus and yellow fever virus, and two neurotropic flaviviruses, Japanese encephalitis virus and Zika virus. We review current knowledge on host-pathogen interactions, virus entry strategies and tropism.
- Subjects :
- Animals
Arthropods virology
Central Nervous System immunology
Central Nervous System metabolism
Central Nervous System virology
Culicidae virology
Disease Vectors
Flavivirus genetics
Flavivirus pathogenicity
Flavivirus Infections transmission
Flavivirus Infections virology
Genome, Viral genetics
Humans
Insect Proteins immunology
Receptors, Virus immunology
Ticks virology
Viral Proteins genetics
Viral Proteins immunology
Viral Proteins metabolism
Virus Internalization
Flavivirus immunology
Flavivirus Infections immunology
Host-Pathogen Interactions immunology
Insect Proteins metabolism
Receptors, Virus metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 30319635
- Full Text :
- https://doi.org/10.3389/fimmu.2018.02180