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Motor activity patterns in acute schizophrenia and other psychotic disorders can be differentiated from bipolar mania and unipolar depression.
- Source :
-
Psychiatry research [Psychiatry Res] 2018 Dec; Vol. 270, pp. 418-425. Date of Electronic Publication: 2018 Oct 02. - Publication Year :
- 2018
-
Abstract
- The purpose of this study was to compare 24-h motor activity patterns between and within three groups of acutely admitted inpatients with schizophrenia and psychotic disorders (n = 28), bipolar mania (n = 18) and motor-retarded unipolar depression (n = 25) and one group of non-hospitalized healthy individuals (n = 28). Motor activity was measured by wrist actigraphy, and analytical approaches using linear and non-linear variability and irregularity measures were undertaken. In between-group comparisons, the schizophrenia group showed more irregular activity patterns than depression cases and healthy individuals. The schizophrenia and mania cases were clinically similar with respect to high prevalence of psychotic symptoms. Although they could not be separated by a formal statistical test, the schizophrenia cases showed more normal amplitudes in morning to evening mean activity and activity variability. Schizophrenia constituted an independent entity in terms of motor activation that could be distinguished from the other diagnostic groups of psychotic and non-psychotic affective disorders. Despite limitations such as small subgroups, short recordings and confounding effects of medication/hospitalization, these results suggest that detailed temporal analysis of motor activity patterns can identify similarities and differences between prevalent functional psychiatric disorders. For this purpose, irregularity measures seem particularly useful to characterize psychotic symptoms and should be explored in larger samples with longer-term recordings, while searching for underlying mechanisms of motor activity disturbances.<br /> (Copyright © 2018. Published by Elsevier B.V.)
- Subjects :
- Actigraphy methods
Adult
Aged
Bipolar Disorder physiopathology
Bipolar Disorder psychology
Depressive Disorder physiopathology
Depressive Disorder psychology
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Psychotic Disorders physiopathology
Psychotic Disorders psychology
Schizophrenia physiopathology
Schizophrenic Psychology
Bipolar Disorder diagnosis
Depressive Disorder diagnosis
Motor Activity physiology
Psychotic Disorders diagnosis
Schizophrenia diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7123
- Volume :
- 270
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 30312969
- Full Text :
- https://doi.org/10.1016/j.psychres.2018.10.004