Back to Search
Start Over
Trans-fatty Acids and Survival in Renal Transplantation.
- Source :
-
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation [J Ren Nutr] 2019 May; Vol. 29 (3), pp. 169-180. Date of Electronic Publication: 2018 Oct 08. - Publication Year :
- 2019
-
Abstract
- Objective: High consumption of trans-fatty acids (TFAs) is associated with increased mortality.<br />Design and Methods: Observational cohort study of 1.988 Norwegian renal transplant recipients with a median follow-up time of 9.6 years. We assessed multivariable adjusted associations between plasma levels of industrial and ruminant TFAs with patient and graft survival. Plasma phospholipid fatty acid levels were determined by gas chromatography at 10 weeks after transplantation.<br />Results: During follow-up, there were 595 deaths, and 805 grafts were lost. Plasma industrial TFA levels dropped from 0.3 wt% in years 1999-2004 to reach a plateau of 0.2 wt% from year 2005 and beyond, whereas plasma levels of ruminant TFAs remained stable throughout the study period. In the former era (years 1999 to 2004, n = 902), we found multivariable adjusted associations between plasma industrial TFA levels and mortality (hazard ratio 4.44, P = .02) and graft loss (hazard ratio 4.22, P = .01). In the latter era (years 2005 to 2011, n = 1,086), there were no associations between plasma industrial TFA levels and patient or graft survival. Plasma ruminant TFAs were not associated with mortality or graft loss in either eras.<br />Conclusion: In this Norwegian transplant cohort, plasma industrial TFA levels dropped from around 0.3 wt% in the former era to 0.2 wt% in the latter era. While plasma industrial TFA was significantly associated with survival in the former era, no associations were found with survival in the latter era. This finding suggests that lowering industrial TFA consumption from modest to low levels could possibly influence health beneficially after renal transplantation.<br /> (Copyright © 2018 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Animals
Cardiovascular Diseases blood
Cardiovascular Diseases mortality
Cohort Studies
Dairy Products
Female
Graft Survival physiology
Humans
Inflammation blood
Kidney Failure, Chronic surgery
Male
Middle Aged
Norway
Phospholipids blood
Proportional Hazards Models
Risk Factors
Trans Fatty Acids administration & dosage
Trans Fatty Acids blood
Kidney Transplantation mortality
Trans Fatty Acids adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8503
- Volume :
- 29
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
- Publication Type :
- Academic Journal
- Accession number :
- 30309780
- Full Text :
- https://doi.org/10.1053/j.jrn.2018.08.003