Back to Search
Start Over
Clinicopathological effect of PLAG1 fusion genes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma with special emphasis on histological features.
- Source :
-
Histopathology [Histopathology] 2019 Feb; Vol. 74 (3), pp. 514-525. Date of Electronic Publication: 2018 Dec 02. - Publication Year :
- 2019
-
Abstract
- Aims: Pleomorphic adenoma gene 1 (PLAG1) rearrangement is well known in pleomorphic adenoma (PA), which is histologically characterised by admixed epithelial and mesenchymal components. Multiple fusion variants of PLAG1 and HMGA2 have been reported; currently, however, little is known regarding the clinicopathological impacts of these fusion types METHODS AND RESULTS: We examined the PLAG1- and HMGA2-related fusion status in 105 PAs and 11 cases of carcinoma ex PAs (CXPA) arising from salivary glands and lacrimal glands to elucidate their correlation to the clinicopathological factors. Forty cases harboured PLAG1 fusion genes: CTNNB1-PLAG1 in 22 cases, CHCHD7-PLAG1 in 14 cases and LIFR-PLAG1 in four cases. Only two cases possessed HMGA2 fusion genes. The mean age of LIFR-PLAG1-positive cases was significantly higher than that of CTNNB1-PLAG1- and CHCHD7-PLAG1-positive cases (P = 0.0358). PAs located in the submandibular gland demonstrated CTNNB1-PLAG1 fusion at a significantly higher rate than other fusions (P = 0.0109). Histologically, PLAG1 fusion-positive cases exhibited chondroid formation and plasmacytoid features more commonly (P = 0.043, P = 0.015, respectively) and myxoid abundant feature less frequently (P = 0.031) than PLAG1 fusion-negative cases. For CXPAs, four CTNNB1-PLAG1 fusions were detected in two salivary duct carcinomas and two myoepithelial carcinomas. Ductal formation was observed frequently (90.9%) in residual PA.<br />Conclusions: The presence of PLAG1 fusion was associated with specific histological features in PA. Detecting the PLAG1 fusion gene and searching residual ductal formation in salivary gland malignant tumours with extensive hyalinisation could be useful for diagnosis.<br /> (© 2018 John Wiley & Sons Ltd.)
- Subjects :
- Adenoma, Pleomorphic mortality
Adenoma, Pleomorphic pathology
Adolescent
Adult
Aged
Carcinoma mortality
Carcinoma pathology
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Salivary Gland Neoplasms mortality
Salivary Gland Neoplasms pathology
Young Adult
Adenoma, Pleomorphic genetics
Carcinoma genetics
DNA-Binding Proteins genetics
Oncogene Fusion genetics
Salivary Gland Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2559
- Volume :
- 74
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 30307055
- Full Text :
- https://doi.org/10.1111/his.13759