A critical appraisal of the measurement of serum 'cholesterol efflux capacity' and its use as surrogate marker of risk of cardiovascular disease.

Authors :: Anastasius M
Luquain-Costaz C
Kockx M
Jessup W
Kritharides L
Source :: Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2018 Oct; Vol. 1863 (10), pp. 1257-1273. Date of Electronic Publication: 2018 Aug 08.
Publication Year :: 2018
Abstract: The 'cholesterol efflux capacity (CEC)' assay is a simple in vitro measure of the capacities of individual sera to promote the first step of the reverse cholesterol transport pathway, the delivery of cellular cholesterol to plasma HDL. This review describes the cell biology of this model and critically assesses its application as a marker of cardiovascular risk. We describe the pathways for cell cholesterol export, current cell models used in the CEC assay with their limitations and consider the contribution that measurement of serum CEC provides to our understanding of HDL function in vivo.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)

Subjects :: Cardiovascular Diseases metabolism
Cholesterol, HDL blood
Humans
Protein Transport
Signal Transduction
Biomarkers blood
Cardiovascular Diseases blood
Cholesterol blood

Language :: English
ISSN :: 1879-2618
Volume :: 1863
Issue :: 10
Database :: MEDLINE
Journal :: Biochimica et biophysica acta. Molecular and cell biology of lipids
Publication Type :: Academic Journal
Accession number :: 30305243
Full Text :: https://doi.org/10.1016/j.bbalip.2018.08.002

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