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Impact of colonoscopic screening in Familial Colorectal Cancer Type X.

Authors :
Hatfield E
Green JS
Woods MO
Warden G
Parfrey PS
Source :
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2018 Nov; Vol. 6 (6), pp. 1021-1030. Date of Electronic Publication: 2018 Oct 09.
Publication Year :
2018

Abstract

Background: Hereditary Non-Polyposis Colorectal cancer is caused by Lynch Syndrome (LS; an autosomal dominant condition) or by Familial Colorectal Cancer Type-X (FCCTX; a condition of high family risk that fulfills Amsterdam criteria). The lifetime risk of developing colorectal cancer (CRC) in FCCTX family members is high and CRC occurs later than in LS.<br />Methods: To determine the impact of primary prevention colonoscopic screening in asymptomatic first-degree relatives of incident CRC cases in 20 families with FCCTX, we compared cancer incidence and survival in 79 males and 83 females, assumed to be at 50% risk of inheriting a genetic CRC susceptibility factor, who entered screening to an unscreened control group from the families, matched for age at entry into screening and for sex.<br />Results: In males, median age at entry into screening was 44.8 years, median follow-up 12.4 years, 12% developed CRC, and 46% died after 30 years of follow-up. Compared to the unscreened group, relative risk of CRC was 0.27 (95% confidence intervals (CI) 0.10-0.71). In screened females, comparable results were 44.5 years at entry, 11.2 years of follow-up, 7.1% developed CRC, and 7.2% died after 30 years of follow-up. The relative risk of CRC compared to the unscreened group was 0.19 (95% CI 0.07-0.48).<br />Conclusion: Primary prevention screening colonoscopy in asymptomatic family members significantly decreased the risk of CRC in FCCTX.<br /> (© 2018 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
2324-9269
Volume :
6
Issue :
6
Database :
MEDLINE
Journal :
Molecular genetics & genomic medicine
Publication Type :
Academic Journal
Accession number :
30300963
Full Text :
https://doi.org/10.1002/mgg3.478