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Nonmalignant and malignant meningioma incidence and survival in the elderly, 2005-2015, using the Central Brain Tumor Registry of the United States.
- Source :
-
Neuro-oncology [Neuro Oncol] 2019 Feb 19; Vol. 21 (3), pp. 380-391. - Publication Year :
- 2019
-
Abstract
- Background: Meningioma incidence increases significantly with age. In the expanding elderly population, we lack complete understanding of population-based trends in meningioma incidence/survival. We provide an updated, comprehensive analysis of meningioma incidence and survival for individuals aged over 65.<br />Methods: Data were obtained from the Central Brain Tumor Registry of the United States (CBTRUS) from 2005-2015 for nonmalignant and malignant meningioma. Age-adjusted incidence rates per 100000 person-years were analyzed by age, sex, race, ethnicity, location, and treatment modalities. Survival was analyzed using Kaplan-Meier and multivariable Cox proportional hazards models for a subset of CBTRUS data.<br />Results: Nonmalignant meningioma incidence doubled from adults age 65-69 years to adults over age 85 years and was significantly greater in females than males for all ages. Malignant meningioma incidence did not differ by sex for any age grouping. Nonmalignant and malignant meningioma incidence was significantly greater in black populations versus others. Nonmalignant meningioma survival was worse with age, in black populations, and in males, including when analyzed by 5-year age groups. Surgical resection and radiation did not improve survival compared with resection alone in nonmalignant meningioma.<br />Conclusions: This study reports increasing nonmalignant meningioma incidence in the elderly, increased incidence in black populations, and in females. In contrast, malignant meningioma incidence did not differ between sexes. Risk of death was higher for black individuals and males. Additionally, radiation did not confer a survival advantage when combined with resection for nonmalignant meningioma. Thus, we identify clinically relevant discrepancies in meningioma incidence/survival that require further study.<br /> (© The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Black or African American
Age Distribution
Aged
Aged, 80 and over
Alaska Natives
Female
Humans
Incidence
Indians, North American
Kaplan-Meier Estimate
Male
Meningeal Neoplasms epidemiology
Meningeal Neoplasms pathology
Meningeal Neoplasms therapy
Meningioma epidemiology
Meningioma pathology
Meningioma therapy
Native Hawaiian or Other Pacific Islander
Neurosurgical Procedures
Proportional Hazards Models
Radiotherapy
Sex Distribution
Sex Factors
United States epidemiology
White People
Ethnicity statistics & numerical data
Meningeal Neoplasms mortality
Meningioma mortality
Survival Rate trends
Subjects
Details
- Language :
- English
- ISSN :
- 1523-5866
- Volume :
- 21
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neuro-oncology
- Publication Type :
- Academic Journal
- Accession number :
- 30295804
- Full Text :
- https://doi.org/10.1093/neuonc/noy162