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Intestinal Dysmotility Syndromes following Systemic Infection by Flaviviruses.
- Source :
-
Cell [Cell] 2018 Nov 15; Vol. 175 (5), pp. 1198-1212.e12. Date of Electronic Publication: 2018 Oct 04. - Publication Year :
- 2018
-
Abstract
- Although chronic gastrointestinal dysmotility syndromes are a common worldwide health problem, underlying causes for these disorders are poorly understood. We show that flavivirus infection of enteric neurons leads to acute neuronal injury and cell death, inflammation, bowel dilation, and slowing of intestinal transit in mice. Flavivirus-primed CD8 <superscript>+</superscript> T cells promote these phenotypes, as their absence diminished enteric neuron injury and intestinal transit delays, and their adoptive transfer reestablished dysmotility after flavivirus infection. Remarkably, mice surviving acute flavivirus infection developed chronic gastrointestinal dysmotility that was exacerbated by immunization with an unrelated alphavirus vaccine or exposure to a non-infectious inflammatory stimulus. This model of chronic post-infectious gastrointestinal dysmotility in mice suggests that viral infections with tropism for enteric neurons and the ensuing immune response might contribute to the development of bowel motility disorders in humans. These results suggest an opportunity for unique approaches to diagnosis and therapy of gastrointestinal dysmotility syndromes.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
CD8-Positive T-Lymphocytes immunology
Flavivirus genetics
Flavivirus Infections immunology
Flavivirus Infections virology
Intestines virology
Leukocytes cytology
Leukocytes immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Neurons pathology
Neurons ultrastructure
RNA, Viral isolation & purification
RNA, Viral metabolism
Syndrome
Flavivirus pathogenicity
Flavivirus Infections pathology
Gastrointestinal Motility
Intestines pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4172
- Volume :
- 175
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 30293866
- Full Text :
- https://doi.org/10.1016/j.cell.2018.08.069