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Cardio-pulmonary elimination of 5-fluorouracil after bolus injection in the hepatic artery.
- Source :
-
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 1987 Feb; Vol. 13 (1), pp. 35-9. - Publication Year :
- 1987
-
Abstract
- Theoretically, administration of 5-fluorouracil (5-FU) into the hepatic artery should improve the clinical response rate by high tumor cell extraction of the drug. However, previous studies in animals and man have also found a major extrahepatic elimination route for 5-FU. In the present study of 7 patients with primary and secondary liver cancer, we have found indications that a considerable elimination of 5-FU takes place in the cardio-pulmonary circuit. Thus, the mean AUC in the hepatic vein was 7185 mumol X min X l-1 and 3792 in a peripheral vein.
- Subjects :
- Adult
Aged
Carcinoma, Hepatocellular drug therapy
Carcinoma, Hepatocellular metabolism
Female
Fluorouracil administration & dosage
Hepatic Artery
Humans
Injections, Intra-Arterial methods
Kinetics
Liver Neoplasms drug therapy
Liver Neoplasms metabolism
Liver Neoplasms secondary
Male
Middle Aged
Time Factors
Fluorouracil metabolism
Lung metabolism
Myocardium metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0748-7983
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 3028867