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The Effect of a Polysaccharide-Based Multinutrient Dietary Supplementation Regimen on Infections and Immune Functioning in Multiple Sclerosis.
- Source :
-
Journal of dietary supplements [J Diet Suppl] 2020; Vol. 17 (2), pp. 184-199. Date of Electronic Publication: 2018 Oct 04. - Publication Year :
- 2020
-
Abstract
- Multiple sclerosis (MS) is a progressive neurodegenerative disease associated with increased infection rates, chronic inflammation, and premature death. Optimization of nutritional status via dietary supplementation may improve immune function in people suffering from MS and lead to decreased rates of infection. Fifteen individuals with a diagnosis of relapsing-remitting MS for an average of 12.4 years (SD =7.4; R = 2, 25) were enrolled in a one-year open-label clinical trial. Participants consumed a broad-spectrum dietary supplement regimen containing polysaccharides, phytochemicals, antioxidants, vitamins, and minerals three times per day. The occurrence of infections and a panel of cytokines, growth factors, and T- and B-cell subsets were assessed at baseline and 12 months. Seven female and 8 male participants with an average age of 51.3 years (SD =7.2; R = 38, 65) completed the study. At the end of the intervention, participants had fewer total infections (M = 7.9, SD =8.1 at baseline and M = 2.5, SD =4.3 at 12-month follow-up). At 12 months, IL-2, TNF-α, EGF, and CD95 + CD34+ significantly increased, while IL-1β significantly decreased. No major adverse effects were reported; only mild gastrointestinal intolerance was reported in four cases. A decreased occurrence of infection was observed in MS patients treated with 12 months of a polysaccharide-based multinutrient dietary supplement. Significant changes were also noted in several key biomarkers that would be physiologically favorable to the MS population. Thus, the results of this study suggest an immunomodulatory effect of the dietary supplement regimen studied.
- Subjects :
- Adult
Aged
Antigens, CD34 metabolism
Biomarkers metabolism
Complementary Therapies
Cytokines metabolism
Epidermal Growth Factor metabolism
Female
Humans
Infections immunology
Male
Middle Aged
Multiple Sclerosis immunology
T-Lymphocyte Subsets metabolism
Tumor Necrosis Factor-alpha metabolism
fas Receptor metabolism
Dietary Supplements
Infections diet therapy
Micronutrients administration & dosage
Multiple Sclerosis diet therapy
Polysaccharides administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1939-022X
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of dietary supplements
- Publication Type :
- Academic Journal
- Accession number :
- 30285512
- Full Text :
- https://doi.org/10.1080/19390211.2018.1495675