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[Influence of primary lymph node status of colorectal cancer on the development of pulmonary metastases and thoracic lymph node metastases].
- Source :
-
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen [Chirurg] 2019 May; Vol. 90 (5), pp. 403-410. - Publication Year :
- 2019
-
Abstract
- Background: The lungs are the second most common organ site for metastases in patients with colorectal cancer (CRC). Lymph node metastasis of CRC represents a prognostic factor for survival.<br />Objective: The present study investigated the influence of CRC lymph node metastasis on lung metastasis, in particular thoracic lymph node metastasis.<br />Material and Methods: A retrospective analysis of 88 patients (n = 56 male) with curative resection of lung metastases of CRC was performed. Primary endpoint: influence of lymph node status of CRC on lung metastases. Secondary endpoints: disease-free survival and overall survival. Statistical evaluation was carried out with SPSS.<br />Results: In 48 patients a positive lymph node status of CRC and in 9 patients an N+ status of lung metastases were determined. The lymph node status of the CRC significantly affected the incidence of synchronous metastases (p = 0.03), disease-free interval until formation of metachronous lung metastases (p = 0.012) and the overall survival of patients with CRC (p = 0.048). The 5‑year survival rate for CRC patients with lung metastases was 48.7% after pulmonary metastasectomy. Thoracic lymph node involvement also significantly affected survival (p = 0.001).<br />Conclusion: Screening for pulmonary metastases should be included in the staging and follow-up of all patients with CRC, especially in patients with a positive lymph node status of the CRC.
Details
- Language :
- German
- ISSN :
- 1433-0385
- Volume :
- 90
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
- Publication Type :
- Academic Journal
- Accession number :
- 30276427
- Full Text :
- https://doi.org/10.1007/s00104-018-0742-y