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Up-regulation of Bone Morphogenetic Protein 7 by 2-Hydroxycinnamaldehyde Attenuates HNSCC Cell Invasion.
- Source :
-
Anticancer research [Anticancer Res] 2018 Oct; Vol. 38 (10), pp. 5747-5757. - Publication Year :
- 2018
-
Abstract
- Background/aim: Few studies have examined the effect of 2'-hydroxycinnamaldehyde (HCA) on head and neck squamous cell carcinoma (HNSCC) cell invasion. This study examined the role of BMP7 on the anti-migration and anti-invasion activity of HCA using HNSCC cells.<br />Materials and Methods: Matrigel invasion and wound healing assays were conducted to investigate cell migration or invasion. BMP7 overexpression vector or siRNA mixture was used for transient regulation of gene expression.<br />Results: HCA attenuated HNSCC cell migration and spheroids Matrigel invasion without cytotoxicity. mRNA and protein expression of BMP7 increased with HCA treatment. Exogenous BMP7 overexpression without HCA treatment attenuated Matrigel invasion of cells. Furthermore, suppression of BMP7 by siRNA alleviated the inhibitory effect of HCA on the invasion of Matrigel by the cell, indicating that BMP7 is responsible for the anti-migration effect of HCA in HNSCC cells.<br />Conclusion: HCA treatment led to a remarkable up-regulation of BMP7, which resulted in the attenuation of HNSCC cell invasion.<br /> (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Apoptosis drug effects
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell metabolism
Cell Proliferation drug effects
Head and Neck Neoplasms drug therapy
Head and Neck Neoplasms metabolism
Humans
Neoplasm Invasiveness
Tumor Cells, Cultured
Bone Morphogenetic Protein 7 metabolism
Carcinoma, Squamous Cell pathology
Cell Movement drug effects
Cinnamates pharmacology
Gene Expression Regulation, Enzymologic drug effects
Gene Expression Regulation, Neoplastic drug effects
Head and Neck Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 38
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 30275196
- Full Text :
- https://doi.org/10.21873/anticanres.12913