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Protein kinase C ι : A versatile oncogene in the lung.
- Source :
-
Molecular & cellular oncology [Mol Cell Oncol] 2018 May 10; Vol. 5 (5), pp. e1190886. Date of Electronic Publication: 2018 May 10 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- We have recently demonstrated that protein kinase C ι (PKC ι ) promotes a stem-like, tumor-initiating cell phenotype in KRAS -driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis. <superscript>1</superscript> Combined PKC ι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS -driven lung adenocarcinoma.
Details
- Language :
- English
- ISSN :
- 2372-3556
- Volume :
- 5
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Molecular & cellular oncology
- Publication Type :
- Academic Journal
- Accession number :
- 30263934
- Full Text :
- https://doi.org/10.1080/23723556.2016.1190886