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Low hair copper concentration is related to a high risk of nonalcoholic fatty liver disease in adults.
Low hair copper concentration is related to a high risk of nonalcoholic fatty liver disease in adults.
- Source :
-
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2018 Dec; Vol. 50, pp. 28-33. Date of Electronic Publication: 2018 Jun 02. - Publication Year :
- 2018
-
Abstract
- Copper, an essential micronutrient, is required for lipid metabolism, mitochondrial function, iron metabolism, and antioxidant defense. Copper deficiency has been linked to alterations in lipid metabolism and various metabolic processes of the liver, including nonalcoholic fatty liver disease (NAFLD); however, most of these studies relied on copper measurements in the blood or tissues. In this study, we investigated the association between hair copper concentration and NAFLD in Korean adults, independent of metabolic syndrome status. Clinical and laboratory parameters, including factors of metabolic syndrome, were analyzed in 751 Korean adults divided into quintiles, according to hair copper concentration. Lower hair copper concentration was significantly correlated with higher body mass index, waist circumference, blood pressure, and lower levels of high-density lipoprotein cholesterol. Subjects with NAFLD showed significantly lower hair copper concentrations, and the risk of NAFLD was significantly higher for the lower hair copper quintile groups even after adjusting for metabolic syndrome-related factors. Overall, this study suggests that lower hair copper concentration could be associated with NAFLD, independent of metabolic syndrome factors.<br /> (Copyright © 2018 Elsevier GmbH. All rights reserved.)
- Subjects :
- Female
Humans
Korea
Lipid Metabolism drug effects
Male
Middle Aged
Waist Circumference drug effects
Copper analysis
Copper toxicity
Hair chemistry
Metabolic Syndrome blood
Metabolic Syndrome chemically induced
Non-alcoholic Fatty Liver Disease blood
Non-alcoholic Fatty Liver Disease chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3252
- Volume :
- 50
- Database :
- MEDLINE
- Journal :
- Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
- Publication Type :
- Academic Journal
- Accession number :
- 30262292
- Full Text :
- https://doi.org/10.1016/j.jtemb.2018.06.001