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Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis.
- Source :
-
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2018 Sep 27; Vol. 37 (1), pp. 239. Date of Electronic Publication: 2018 Sep 27. - Publication Year :
- 2018
-
Abstract
- Background: The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy between, on the one hand, genomic studies showing the binding of c-Myc to all active promoters and, on the other hand, the evidence that only 60% or less of the binding sites have E-box sequences.<br />Main Body: In this review, we provide support to the hypothesis that the cooperation of c-Myc with transcriptional cofactors mediates c-Myc-induced cellular functions. We produce evidence that recently identified cofactors are involved in c-Myc control of survival mechanisms of cancer cells.<br />Conclusion: The identification of new c-Myc cofactors could favor the development of therapeutic strategies able to compensate the difficulty of targeting c-Myc.
Details
- Language :
- English
- ISSN :
- 1756-9966
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of experimental & clinical cancer research : CR
- Publication Type :
- Academic Journal
- Accession number :
- 30261904
- Full Text :
- https://doi.org/10.1186/s13046-018-0912-2