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Sentinels at the wall: epithelial-derived cytokines serve as triggers of upper airway type 2 inflammation.
- Source :
-
International forum of allergy & rhinology [Int Forum Allergy Rhinol] 2019 Jan; Vol. 9 (1), pp. 93-99. Date of Electronic Publication: 2018 Sep 10. - Publication Year :
- 2019
-
Abstract
- Recent evidence has demonstrated an expanding role of respiratory epithelial cells in immune surveillance and modulation. Studies have been focusing on the earliest events that link epithelial injury to downstream inflammatory responses. Cytokines produced by and released from respiratory epithelial cells are among these early trigger signals. Epithelial-derived cytokines, namely thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, and IL-33, have come to the forefront of recent investigations. Each of these 3 cytokines has been implicated in chronic rhinosinusitis (CRS), asthma, and atopy. Herein we review studies elucidating the roles of epithelial-derived cytokines in the pathobiology of upper airway disease, with particular emphasis on type 2 inflammatory conditions.<br /> (© 2018 ARS-AAOA, LLC.)
- Subjects :
- Animals
Cytokines metabolism
Humans
Interleukin-17 metabolism
Interleukin-33 metabolism
Thymic Stromal Lymphopoietin
Asthma immunology
Hypersensitivity immunology
Inflammation immunology
Respiratory Hypersensitivity immunology
Respiratory Mucosa immunology
Sinusitis immunology
Th2 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2042-6984
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International forum of allergy & rhinology
- Publication Type :
- Academic Journal
- Accession number :
- 30260580
- Full Text :
- https://doi.org/10.1002/alr.22206