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The influence of changing dose rate patterns from inhaled beta-gamma emitting radionuclide on lung cancer.
- Source :
-
International journal of radiation biology [Int J Radiat Biol] 2018 Nov; Vol. 94 (11), pp. 955-966. Date of Electronic Publication: 2018 Sep 26. - Publication Year :
- 2018
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Abstract
- Purpose: Dose and dose rate are both appropriate for estimating risk from internally deposited radioactive materials. We investigated the role of dose rate on lung cancer induction in Beagle dogs following a single inhalation of strontium-90 ( <superscript>90</superscript> Sr), cerium-144 ( <superscript>144</superscript> Ce), yttrium-91 ( <superscript>91</superscript> Y), or yttrium-90 ( <superscript>90</superscript> Y). As retention of the radionuclide is dependent on biological clearance and physical half-life a representative quantity to describe this complex changing dose rate is needed.<br />Materials and Methods: Data were obtained from Beagle dog experiments from the Inhalation Toxicology Research Institute. The authors selected the dose rate at the effective half-life of each radionuclide (DR <subscript>ef</subscript> ).<br />Results: Dogs exposed to DRef (1-100 Gy/day) died within the first year after exposure from acute lung disease. Dogs exposed at lower DRef (0.1-10 Gy/day) died of lung cancer. As DR <subscript>ef</subscript> decreased further (<0.1 Gy/day <superscript>90</superscript> Sr, <0.5 Gy/day <superscript>144</superscript> Ce, <0.9 Gy/day <superscript>91</superscript> Y, <8 Gy/day <superscript>90</superscript> Y), survival and lung cancer frequency were not significantly different from control dogs.<br />Conclusion: Radiation exposures resulting from inhalation of beta-gamma emitting radionuclides that decay at different rates based on their effective half-life, leading to different rates of decrease in dose rate and cumulative dose, is less effective in causing cancer than acute low linear energy transfer exposures of the lung.
Details
- Language :
- English
- ISSN :
- 1362-3095
- Volume :
- 94
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of radiation biology
- Publication Type :
- Academic Journal
- Accession number :
- 30257126
- Full Text :
- https://doi.org/10.1080/09553002.2018.1511929