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The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance.
- Source :
-
Journal of immunology research [J Immunol Res] 2018 Sep 04; Vol. 2018, pp. 3930750. Date of Electronic Publication: 2018 Sep 04 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Autoimmune regulator (AIRE), whose gene mutation is considered to be a causative factor of autoimmune polyglandular syndrome type 1 (APS1), is an important transcriptional regulator. Studies on the role of AIRE in the central immune system have demonstrated that AIRE can eliminate autoreactive T cells by regulating the expression of a series of tissue specific antigens promiscuously in medullary thymic epithelial cells (mTECs) and induce regulatory T cell (Treg) production to maintain central immune tolerance. However, the related research of AIRE in peripheral tolerance is few. In order to understand the current research progress on AIRE in peripheral tolerance, this review mainly focuses on the expression and distribution of AIRE in peripheral tissues and organs, and the role of AIRE in peripheral immune tolerance such as regulating Toll-like receptor (TLR) expression and the maturation status of antigen presenting cells (APCs), inducing T cell tolerance and differentiation. This review will show us that AIRE also plays an indispensable role in the periphery.
- Subjects :
- Animals
Autoimmunity genetics
Cell Differentiation
Gene Expression Regulation
Humans
Mutation genetics
Peripheral Tolerance
Polyendocrinopathies, Autoimmune genetics
Toll-Like Receptors metabolism
Transcription Factors genetics
AIRE Protein
Antigen-Presenting Cells physiology
Polyendocrinopathies, Autoimmune immunology
T-Lymphocytes immunology
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2314-7156
- Volume :
- 2018
- Database :
- MEDLINE
- Journal :
- Journal of immunology research
- Publication Type :
- Academic Journal
- Accession number :
- 30255105
- Full Text :
- https://doi.org/10.1155/2018/3930750