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Sitagliptin for prevention of stress hyperglycemia in patients without diabetes undergoing general surgery: A pilot randomized study.
- Source :
-
Journal of diabetes and its complications [J Diabetes Complications] 2018 Dec; Vol. 32 (12), pp. 1091-1096. Date of Electronic Publication: 2018 Sep 01. - Publication Year :
- 2018
-
Abstract
- Aim: We investigated if a dipeptidyl peptidase-4 inhibitor, sitagliptin, can prevent perioperative stress hyperglycemia in patients without prior history of diabetes mellitus undergoing general surgery.<br />Methods: This double-blind pilot trial randomized general surgery patients to receive sitagliptin (n = 44) or placebo (n = 36) once daily, starting one day prior to surgery and continued during the hospital stay. The primary outcome was occurrence of stress hyperglycemia, defined by blood glucose (BG) >140 mg/dL and >180 mg/dL after surgery. Secondary outcomes included: length-of-stay, ICU transfers, hypoglycemia, and hospital complications.<br />Results: BG >140 mg/dL was present in 44 (55%) of subjects following surgery. There were no differences in hyperglycemia between placebo and sitagliptin (56% vs. 55%, p = 0.93). BG >180 mg/dL was observed in 19% and 11% of patients treated with placebo and sitagliptin, respectively, p = 0.36. Both treatment groups had resulted in similar postoperative BG (148.9 ± 29.4 mg/dL vs. 146.9 ± 35.2 mg/dL, p = 0.73). There were no differences in length-of-stay (4 vs. 3 days, p = 0.84), ICU transfer (3% vs. 5%, p = 1.00), hypoglycemia <70 mg/dL (6% vs. 11%, p = 0.45), and complications (14% vs. 18%, p = 0.76).<br />Conclusion: Preoperative treatment with sitagliptin did not prevent stress hyperglycemia or complications in individuals without diabetes undergoing surgery.<br /> (Published by Elsevier Inc.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Blood Glucose drug effects
Blood Glucose metabolism
Dipeptidyl-Peptidase IV Inhibitors therapeutic use
Double-Blind Method
Feasibility Studies
Female
Hospitalization
Humans
Hyperglycemia etiology
Male
Middle Aged
Pilot Projects
Stress, Psychological blood
Stress, Psychological complications
Surgical Procedures, Operative adverse effects
Young Adult
Hyperglycemia prevention & control
Preoperative Care methods
Sitagliptin Phosphate therapeutic use
Stress, Psychological drug therapy
Surgical Procedures, Operative psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-460X
- Volume :
- 32
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of diabetes and its complications
- Publication Type :
- Academic Journal
- Accession number :
- 30253968
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2018.08.014