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Investigation of the Relationship Between Fok1 and Col1A1 Gene Polymorphisms and Development of Treatment-Related Bone Complications in Children with Acute Lymphoblastic Leukemia
- Source :
-
Turkish journal of haematology : official journal of Turkish Society of Haematology [Turk J Haematol] 2019 Feb 07; Vol. 36 (1), pp. 12-18. Date of Electronic Publication: 2018 Sep 25. - Publication Year :
- 2019
-
Abstract
- Objective: In acute lymphoblastic leukemia (ALL), various clinical risk factors and genetic predispositions contribute to the development of bone complications during and after chemotherapy. In this study, we aimed to investigate whether vitamin D receptor ( VDR ) Fok1 and collagen protein Col1A1 Sp1-binding site gene polymorphisms, which are important in bone mineral and matrix formation, have effects on the development of bone abnormalities in childhood ALL survivors.<br />Materials and Methods: Fifty children with ALL who were treated with the ALL Berlin-Frankfurt-Muenster-95 protocol between 1998 and 2008 and were followed for at least 7 years were enrolled. The control group consisted of 96 healthy children. VDR Fok1 and Col1A1 Sp1-binding site gene polymorphisms were analyzed by polymerase chain reaction and restriction fragment length polymorphism. Bone mineral density (BMD) and markers of bone metabolism were all noted. All patients who presented with pain in the joints were examined for bone pathologies while on chemotherapy or during long-term follow-up.<br />Results: Low BMD (16%), osteoporosis (12%), and osteonecrosis (8%) were present in a total of 18 patients (36%). The frequency of osteonecrosis and total bone abnormalities was significantly higher in children aged ≥10 years (p=0.001). The risk of low BMD and osteonecrosis was higher in those with vitamin D deficiency. Only the Col1A1 Sp1-binding site gene polymorphism showed a significant association in ALL patients with osteonecrosis.<br />Conclusion: The development of therapy-induced bone mineral loss and osteonecrosis in children with ALL is frequent and the risk is especially higher in children aged ≥10 years and with vitamin D deficiency. The association between Col1A1 Sp1-binding site gene polymorphisms and osteonecrosis has to be assessed in a larger group of ALL survivors.
- Subjects :
- Bone Density
Child
Child, Preschool
Collagen Type I, alpha 1 Chain
Female
Genetic Predisposition to Disease
Humans
Infant
Infant, Newborn
Male
Osteonecrosis genetics
Osteonecrosis pathology
Osteoporosis genetics
Osteoporosis pathology
Polymorphism, Genetic
Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology
Collagen Type I genetics
Osteonecrosis etiology
Osteoporosis etiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
Receptors, Calcitriol genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1308-5263
- Volume :
- 36
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Turkish journal of haematology : official journal of Turkish Society of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 30251958
- Full Text :
- https://doi.org/10.4274/tjh.galenos.2018.2018.0221