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Cardiovascular alterations in the rabbit infused with platelet activating factor (PAF): effect of kadsurenone, a PAF-receptor antagonist.
- Source :
-
International journal of tissue reactions [Int J Tissue React] 1986; Vol. 8 (6), pp. 497-504. - Publication Year :
- 1986
-
Abstract
- The ECG and haemodynamic alterations caused by the i.v. infusion of platelet-activating factor (PAF) in the rabbit were studied after pretreatment with Kadsurenone, a specific PAF-receptor antagonist. Infusion of PAF at 0.8 microgram/kg in the rabbit caused important ECG changes, such as ST-segment depression and conduction arrhythmias, concomitantly with a marked reduction in left ventricular systolic pressure, mean arterial pressure and cardiac output, with a rise in total peripheral resistances and mean right atrial pressure. These physiological parameters became maximal at 75-120 seconds after PAF challenge, and returned to near prechallenge values within 25-60 minutes. Pretreatment with Kadsurenone, administered either intravenously (0.014 M, 1 ml/kg) or intraperitoneally (0.14 M, 1 ml/kg), exerted a quite complete protective effect in regard to the ECG changes and caused a significant reduction in the magnitude of all the haemodynamic alterations observed after intravenous infusion of PAF (0.8 microgram/kg). These results suggest that Kadsurenone is an effective inhibitor of PAF-induced cardiovascular changes in the rabbit, probably due to its competitive antagonism against PAF binding to specific receptors.
- Subjects :
- Animals
Cardiovascular Physiological Phenomena
Electrocardiography
Female
Hemodynamics drug effects
Male
Platelet Activating Factor antagonists & inhibitors
Rabbits
Benzofurans pharmacology
Cardiovascular System drug effects
Lignans
Platelet Activating Factor physiology
Platelet Membrane Glycoproteins
Receptors, Cell Surface drug effects
Receptors, G-Protein-Coupled
Subjects
Details
- Language :
- English
- ISSN :
- 0250-0868
- Volume :
- 8
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of tissue reactions
- Publication Type :
- Academic Journal
- Accession number :
- 3025124