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Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review.
- Source :
-
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2019 Jan; Vol. 27 (1), pp. 69-86. Date of Electronic Publication: 2018 Sep 25. - Publication Year :
- 2019
-
Abstract
- Purpose: To describe the impairments in physical fitness in individuals who were previously diagnosed and treated for childhood cancer.<br />Methods: Using the PRISMA-guidelines, a systematic search was performed in PubMed, Web of Science, and Embase using a combination of the following predefined keywords: "exercise capacity" OR "aerobic capacity" OR "fitness" OR "cardiorespiratory fitness" OR "cardiopulmonary fitness" OR "physical fitness" OR "exercise testing" OR "exercise tolerance" OR "exercise" OR "oxygen consumption" AND "leukemia" OR "childhood cancer" OR "childhood cancer survivors (CCS)". Studies that met our inclusion criteria were reviewed on methodological quality, while the Newcastle-Ottawa Scale was used for evidence synthesis.<br />Results: A total of 2644 articles were identified from the database search. After screening based on the eligibility (abstracts) and inclusion (full texts) criteria, 49 articles remained. Even though the risk-of-bias scores in the studies were generally low, yet the results from those with high-quality studies revealed that poor fitness levels were prevalent in individuals with acute lymphoblastic leukemia, brain tumor, and mixed cancer histories, compared to healthy controls.<br />Conclusions: A global glance at CCS shows poor levels of fitness that is continuous and life-long even after active cancer treatment has ended. Nevertheless, the results presented in this review were based on a limited number of high-quality studies suggesting the need to for additional clinical trials in the topic area.
- Subjects :
- Age of Onset
Child
Exercise physiology
Humans
Neoplasms epidemiology
Neoplasms physiopathology
Neoplasms rehabilitation
Oxygen Consumption
Precursor Cell Lymphoblastic Leukemia-Lymphoma physiopathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma rehabilitation
Time Factors
Cancer Survivors
Cardiorespiratory Fitness physiology
Exercise Tolerance physiology
Physical Fitness physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1433-7339
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30251066
- Full Text :
- https://doi.org/10.1007/s00520-018-4483-8