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Real world survival data of a rare malignancy: Anal cancer results in HIV negative patients from Turkey.
Real world survival data of a rare malignancy: Anal cancer results in HIV negative patients from Turkey.
- Source :
-
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology [Turk J Gastroenterol] 2018 Jul; Vol. 29 (4), pp. 411-418. - Publication Year :
- 2018
-
Abstract
- Background/aims: An organ preservation approach using chemoradiotherapy has been established for anal cancer. This retrospective cohort study aimed to define the clinico-demographic characteristics and outcomes of cases of human immunodeficiency virus (HIV)-negative anal carcinoma during a period of 20 years in a single comprehensive cancer institute.<br />Materials and Methods: This was a single-center retrospective cohort study of patients who were treated between January 1995 and January 2015. The primary outcome measures that were investigated included overall survival (OS), progression-free survival (PFS), colostomy rates, and colostomy-free survival (CFS).<br />Results: A total of 28 patients who were principally treated with standard 5-fluorouracil + mitomycin combination chemoradiotherapy were eligible for analysis. The 3- and 5-year PFS rates were 92.4% and 63%, respectively. The lower T stage was found to be associated with a prolonged PFS (p=0.001). The 3- and 5-year CFS rates were 84.3% and 74.9%, respectively. A longer CFS was observed with lower T stages (p=0.05). At the last follow-up, 75% of the patients with anal cancer were alive, and 71.4% of the patients were disease free. The median OS was not reached with a median follow-up of 54 months (range, 6-115 months). The 3- and 5-year OS rates were 82% and 71.1%, respectively. No late toxicity was observed during the follow-up period.<br />Discussion: The short- and long-term prognoses of HIV-negative patients with anal squamous cell carcinoma were good, and low-grade toxicity was rare, thereby demonstrating that these patients can be successfully treated in a real-life setting with favorable outcomes.
- Subjects :
- Adult
Aged
Anus Neoplasms therapy
Anus Neoplasms virology
Carcinoma, Squamous Cell therapy
Carcinoma, Squamous Cell virology
Chemoradiotherapy mortality
Female
Fluorouracil administration & dosage
Humans
Male
Middle Aged
Mitomycin administration & dosage
Neoplasm Staging
Progression-Free Survival
Retrospective Studies
Survival Rate
Turkey epidemiology
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Anus Neoplasms mortality
Carcinoma, Squamous Cell mortality
HIV Seronegativity
Subjects
Details
- Language :
- English
- ISSN :
- 2148-5607
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 30249555
- Full Text :
- https://doi.org/10.5152/tjg.2018.17660