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Intergrating conventional MRI, texture analysis of dynamic contrast-enhanced MRI, and susceptibility weighted imaging for glioma grading.
- Source :
-
Acta radiologica (Stockholm, Sweden : 1987) [Acta Radiol] 2019 Jun; Vol. 60 (6), pp. 777-787. Date of Electronic Publication: 2018 Sep 23. - Publication Year :
- 2019
-
Abstract
- Background: The application of conventional magnetic resonance imaging (MRI) in glioma grading is limited and non-specific.<br />Purpose: To investigate the application values of MRI, texture analysis (TA) of dynamic contrast-enhanced MRI (DCE-MRI) and intratumoral susceptibility signal (ITSS) on susceptibility weighted imaging (SWI), alone and in combination, for glioma grading.<br />Material and Methods: Fifty-two patients with pathologically confirmed gliomas who underwent DCE-MRI and SWI were enrolled in this retrospective study. Conventional MRIs were evaluated by the VASARI scoring system. TA of DCE-MRI-derived parameters and the degree of ITSS were compared between low-grade gliomas (LGGs) and high-grade gliomas (HGGs). The diagnostic ability of each parameter and their combination for glioma grading were analyzed.<br />Results: Significant statistical differences in VASARI features were observed between LGGs and HGGs ( P < 0.05), of which the enhancement quality had the highest area under the curve (AUC) (0.873) with 93.3% sensitivity and 80% specificity. The TA of DCE-MRI derived parameters were significantly different between LGGs and HGGs ( P < 0.05), of which the uniformity of K <superscript>trans</superscript> had the highest AUC (0.917) with 93.3% sensitivity and 90% specificity. The degree of ITSS was significantly different between LGGs and HGGs ( P < 0.001). The AUC of the ITSS was 0.925 with 93.3% sensitivity and 90% specificity. The best discriminative power was obtained from a combination of enhancement quality, K <superscript>trans</superscript> - uniformity, and ITSS, resulting in 96.7% sensitivity, 100.0% specificity, and AUC of 0.993.<br />Conclusion: Combining conventional MRI, TA of DCE-MRI, and ITSS on SWI may help to improve the differentiation between LGGs and HGGs.
- Subjects :
- Adult
Aged
Brain diagnostic imaging
Brain pathology
Brain Neoplasms diagnostic imaging
Female
Glioma diagnostic imaging
Humans
Male
Middle Aged
Neoplasm Grading
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Brain Neoplasms pathology
Contrast Media
Glioma pathology
Image Enhancement methods
Magnetic Resonance Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0455
- Volume :
- 60
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Acta radiologica (Stockholm, Sweden : 1987)
- Publication Type :
- Academic Journal
- Accession number :
- 30244590
- Full Text :
- https://doi.org/10.1177/0284185118801127