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Effect of a heme-peptide derived from cytochrome-c on lipid peroxidation. I. Effects on brain microsomes.
- Source :
-
Acta biochimica et biophysica Hungarica [Acta Biochim Biophys Hung] 1986; Vol. 21 (1-2), pp. 3-11. - Publication Year :
- 1986
-
Abstract
- Heme-nonapeptide inhibits NADH and NADPH dependent lipid peroxidation of brain microsomes in the presence or absence of ADP-Fe complex. The transient accumulation of lipid peroxides during NADH or NADPH dependent, ADP-Fe stimulated lipid peroxidation, is inhibited by heme-nonapeptide. Oxygen consumption of brain microsomes in the presence of NADH or NADPH is stimulated by heme-nonapeptide. Reduction of cytochrome-c and nitro-tetrazolium-blue by O2- generated by xanthine oxidase is inhibited by heme-nonapeptide.
- Subjects :
- Adenosine Diphosphate analogs & derivatives
Adenosine Diphosphate pharmacology
Animals
Brain drug effects
Brain metabolism
In Vitro Techniques
Malondialdehyde metabolism
Microsomes drug effects
NAD metabolism
NADP metabolism
Oxygen Consumption drug effects
Rats
Rats, Inbred Strains
Superoxides physiology
Cytochrome c Group pharmacology
Cytochromes c
Lipid Peroxides biosynthesis
Microsomes metabolism
Peptide Fragments pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0237-6261
- Volume :
- 21
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Acta biochimica et biophysica Hungarica
- Publication Type :
- Academic Journal
- Accession number :
- 3024427