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Detection of anti-neutrophil cytoplasmic antibodies in dogs with immune-mediated inflammatory diseases.
- Source :
-
Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 2018 Sep; Vol. 203, pp. 47-51. Date of Electronic Publication: 2018 Aug 16. - Publication Year :
- 2018
-
Abstract
- Anti-neutrophil cytoplasmic antibody (ANCA) is a type of autoantibody against neutrophil cytoplasm. In veterinary medicine, few studies have reported the detection of ANCA in dogs, and most of these studies were performed in dogs with inflammatory bowel disease (IBD). The aim of this study was to evaluate whether ANCA is detected in dogs with immune-mediated inflammatory diseases (IMIDs) other than IBD. Serum samples were collected before treatment initiation from 40 client-owned dogs with various diseases and 22 healthy beagle dogs; the dogs were classified into two groups: IMID group (n = 16) and control group (n = 46). ANCA was detected using the indirect fluorescent antibody test. Of the 16 dogs in the IMID group, 13 (81.3%) tested positive for ANCA. In contrast, of the 46 dogs in the control group, 13 (28.03%) tested positive for ANCA. Moreover, a significant association between ANCA positivity and IMIDs was identified in the IMID group than in the control group (P = 0.0003). In the control group, however, dogs with bacterial infection showed a relatively high rate of ANCA positivity. Therefore, ANCA positivity was observed in dogs with both IMIDs and bacterial infection. This suggested that ANCA positivity is associated with diseases accompanied by neutrophil activation and infiltration.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Antibodies, Antineutrophil Cytoplasmic blood
Arthritis blood
Arthritis immunology
Arthritis veterinary
Autoimmune Diseases blood
Autoimmune Diseases immunology
Case-Control Studies
Dog Diseases blood
Dogs
Female
Fluorescent Antibody Technique, Indirect veterinary
Male
Neutrophils immunology
Panniculitis blood
Panniculitis immunology
Panniculitis veterinary
Antibodies, Antineutrophil Cytoplasmic immunology
Autoimmune Diseases veterinary
Dog Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2534
- Volume :
- 203
- Database :
- MEDLINE
- Journal :
- Veterinary immunology and immunopathology
- Publication Type :
- Academic Journal
- Accession number :
- 30243372
- Full Text :
- https://doi.org/10.1016/j.vetimm.2018.08.005